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Clinical consideration should be given to post-inflammatory hyperpigmentation risk with injectable formulations in darker skin types, requiring careful injection technique and avoidance of trauma

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Trx in particular has been shown to regulate several signal transduction pathways involving ASK-1, NF-B, PTEN, and AP-1 and the NLRP-3 inflammasome (41), suggesting that the switch between thiol/disulfide is a critical component of intracellular signaling machinery that turns protein targets on/off to activate or deactivate specific signaling pathways

IG = (62) and CG = (16) were intermediate and lower than white bread IG = (69) and CG = (18), with no difference in postprandial insulin