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Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

Dans un essai clinique multicentrique europen, la supplmentation en L-carnitine (sous forme de propionyl L-carnitine 2 g/jour pendant 12 mois) chez des patients atteints de claudication modre svre a permis d'obtenir une amlioration significative en termes de distance maximale parcourue et de qualit de vie perue par rapport aux patients recevant uniquement des placebos

doi: 10.1111/j.1471-4159.2010.06807.x