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For example, chronic alcohol feeding in diethylnitrosamine (DEN)-induced HCC mice leads to reduced antitumor CD8+ T cells and an increase in tumor-associated macrophages (TAMs), which tend to polarize toward the M2 phenotype after alcohol exposure (89)

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Previous studies also supported these findings as the induction of expression in respective genes has been observed in methylated promoters (Pruitt et al., 2006

Major depressive disorder, neuroticism, suicidal behaviors, and depression severity are associated with cytokine networks and their intricate interactions with metabolic syndrome
