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For example, chronic alcohol feeding in diethylnitrosamine (DEN)-induced HCC mice leads to reduced antitumor CD8+ T cells and an increase in tumor-associated macrophages (TAMs), which tend to polarize toward the M2 phenotype after alcohol exposure (89)

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Previous studies also supported these findings as the induction of expression in respective genes has been observed in methylated promoters (Pruitt et al., 2006

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Major depressive disorder, neuroticism, suicidal behaviors, and depression severity are associated with cytokine networks and their intricate interactions with metabolic syndrome

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