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Regulation of the Nrf2/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: implications for disease treatment

doi: 10.1016/j.sxmr.2017.02.004

The second is pharmacological: what side effects, treatment burden, and long-term trade-offs come with using medication to push levels that low
Target Gene Activation: COL11A1 Upregulation: It specifically acts as a "matrikine," mimicking Type XI collagen breakdown to signal the synthesis of new Type XI collagen (critical for nucleating Type II fibrils)

Int J Mol Sci 25(5):2774 Spanoudaki M et al (2024) Curcumin as a multifunctional spice ingredient against mental disorders in humans: current clinical studies and bioavailability concerns