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Further, the review process was organized using the PICO (Participant, Intervention, Comparison, and Outcomes) framework, as described below: Participants: studies involving male patients or animals with reproductive system diseases or dysfunction

In NRK-52E cells, TGF-1 stimulation considerably upregulated the expression levels of p53 and nuclear Nrf2 protein, which was consistent with the trend of erastin-induced cells and animal models, indicating that Nrf2 is probably related to ferroptosis under diabetic conditions[83]

doi: 10.1016/j.mam.2008.05.005 129 WangLAhnYJAsmisR

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Also, the GMP enzyme has an oligomer-forming monomer (protomer), and their oligomers vary in size and organization