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Using the Augmented Hill-Climb optimization algorithm, the framework efficiently balances multiple objectives, including protein-ligand complementarity, leading to the generation of chemically novel ligands for A2ARmany of which are absent from commercial libraries

Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: A randomized, double-blind, placebo-controlled study

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doi: 10.1038/s41514-022-00083-0

Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13(BN) rats