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Mandarano AH, Maya J, Giloteaux L, Peterson DL, Maynard M, Gottschalk CG, et al

How long is the proposed treatment course, and what are the criteria for stopping

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Improves Heart Health and Reduces the Risk of Cardiovascular Disease Maintaining adequate levels of Vitamin B12 is important for heart health, as B12 helps regulate levels of homocysteine, an amino acid that is associated with an increased risk of cardiovascular disease when present in high amounts

Interim phase 1 data in heavily pretreated mCRC showed 28% ORR and 94% DCR across prioritized dose levels, 43% ORR at 10 mg/kg, and median PFS 5.8 months