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Pharmacology & Therapeutics

In addition, xenograft animal models further confirmed the effect on proliferation

Necroptosis Necroptosis is a regulated form of cell death orchestrated by the interplay of key proteins, including receptor-interacting serine/threonine kinase 1 (RIPK1), receptor-interacting serine/threonine kinase 3 (RIPK3), and mixed lineage kinase domain-like pseudokinase (MLKL)

They are primarily used as adjunct therapy to levodopa to reduce motor fluctuations, particularly the wearingoff phenomenon [3, 6]

Interestingly, they discovered that hepatocyte-derived exosomal miR-192-5p did not induce M2 macrophage polarization, and neither did exosomes from PA-treated HepG2 cells affect M2 macrophage activation