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Blood 127:829838 Kato GJ, Steinberg MH, Gladwin MT (2017) Intravascular hemolysis and the pathophysiology of sickle cell disease

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They argue its safety concerns are ill-defined and that regulators are too focused on efficacy for products that are intended for use only on a case-by-case basis

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Vitamin B12 is required for normal cell function, so a deficiency over a long period of time may impact growth, digestion, blood cell production, and the nervous system