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In adults, these defects are usually characterized by the accumulation of medium-chain and long-chain (3-hydroxy) carnitine derivatives, and they are associated with lipotoxicity in several organs that can lead to life-threatening complications and comorbidities

Look AHEAD Research Group One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD Study Obesity (Silver Spring) 20 4: 783-93

A note on thyroid hormones: Carnitine has traditionally been used by individuals with hyperthyroidism to help with symptoms resulting from hyperthyroid-induced carnitine depletion (such as muscle wasting), so scientists initially believed that carnitine acted like an antagonist or a thyroid hormone receptor blocker, and cautioned against using carnitine in hypothyroidism

Data availability The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request

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