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On review in the endocrinology clinic prominent forehead, depressed nasal bridge and a high-pitched voice were noted

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Wang Y, Gao W, Shi X, Ding J, Liu W, He H, et al

The traditional classification of microglial phenotypes into binary M1 (pro-inflammatory) and M2 (anti-inflammatory/neuroprotective) categories has provided a useful conceptual framework, though it is increasingly recognized as an oversimplification of their functional diversity (Figure 5)
