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The elderly population is more susceptible to OS, caused by a deterioration in the efficacy of their endogenous antioxidant system and causes failure of several defense mechanisms to respond to reactive species (ROS, RNS)

In untreated cells in this study, rapamycin-induced autophagy failed to induce cell death [175]

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For example, in treated animals, there are notable alterations in gut microbiota composition, including increased levels of beneficial bacteria such as Lactobacillus and Prevotella, alongside reductions in bacteria linked to inflammation