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The mechanistic difference translates directly to side-effect profiles: cagrilintide causes nausea and vomiting in 3040% of subjects during dose titration (similar to GLP-1 agonists), while tesofensine produces insomnia, dry mouth, and increased heart rate in 2035% due to its sympathomimetic effects
Source: Melson, E., Ashraf, U., Papamargaritis, D., & Davies, M
Degradation of drug delivery nanocarriers and payload release: a review of physical methods for tracing nanocarrier biological fate
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