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As mentioned, no other medical intervention except for drug cessation and liver function monitoring has been made in the most cases of antithyroid drugs-induced hepatotoxicity.8,27,98 However, intra vascular glutathione was founded to be an effective treatment in a case of methimazole-induced hepatotoxicity and lowered transaminase levels in the patient.99 As mentioned, glutathione (GSH) has been proven to play a critical role in preventing methimazole-induced hepatic injury in different experimental models.41,51,52 Hence, using glutathione in patients with methimazole-induced liver injury seems to be a reasonable choice

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Therefore, the preservation of cellular homeostasis emerges as the cornerstone of life, encompassing a multitude of regulatory mechanisms such as intracellular molecular interactions, metabolic homeostasis, and the maintenance of energy balance

"Double-blind" means neither patients nor doctors know who is in which group eliminating both placebo effects and evaluator bias