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For example, circTRIM1 enhances MARCKS translocation and activates the PI3K/AKT/mTOR signaling pathway, promoting chemoresistance to doxorubicin in TNBC

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Interference with gut ecological balance increases intestinal barrier permeability, allowing bacterial translocation

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Takahashi et al., 2025)

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Understanding how mitochondrial dysfunction can alter these processes is essential in researching rare diseases

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