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For example, circTRIM1 enhances MARCKS translocation and activates the PI3K/AKT/mTOR signaling pathway, promoting chemoresistance to doxorubicin in TNBC

Interference with gut ecological balance increases intestinal barrier permeability, allowing bacterial translocation

Takahashi et al., 2025)

Understanding how mitochondrial dysfunction can alter these processes is essential in researching rare diseases
