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Reduced availability of 5,10-methylene-THF results in problems with DNA synthesis, and ultimately in ineffective production cells with rapid turnover, in particular blood cells, and also intestinal wall cells which are responsible for absorption

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Park JH, et al

The metabolism of the branched-chain amino acids is critical to overall nitrogen homeostasis in the brain and to the maintenance of proper levels of the excitatory neurotransmitter, glutamate

CYP enzymes including CYP2D6 and CYP2C9 are part of the cytochrome P450 family primarily involved in xenobiotic metabolism

doi: 10.1016/j.npep.2024.102440