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321 Ligandreceptor binding results in the release of the Notch intracellular domain (NICD) and NICD interaction with recombination signal-binding protein immunoglobulin kappa J (RBPJ) to initiate the transcription of downstream target genes such as HES/HEY

doi:10.1007/s10517-017-3919-3 PMID: 29124531 Sychowski G, Cierniak A

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ALA acts as a cofactor for pyruvate dehydrogenase (PDH), activating it and inhibiting pyruvate dehydrogenase kinase