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G., et al., Antitumor Effect of Isoquercetin on Tissue Vasohibin Expression and Colon Cancer Vasculature, Oncotarget 13 (2022): 307318

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ICD refers to a specific form of regulated cell death in which tumor cells undergo death and release damage-associated molecular patterns (DAMPs) and other signaling molecules, thereby reshaping the tumor immune microenvironment (TIME)

In the first and second stages, lab testing will show declining levels of vitamin B12 and holotranscobalamin (transporter of B12), while MMA and homocysteine levels will remain within or around the normal range
