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In conclusion, the available studies suggest that targeting glutamine metabolism can inhibit mitochondrial oxidative phosphorylation, reduce glutathione production, disrupt redox homeostasis, and inhibit mTORC1 activation in AML cells
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Ammonia concentration in the brain is regulated by the mitochondrial glutamate dehydrogenase, which catalyzes the reversible conversion of glutamate to -ketoglutarate and ammonia, using NADH or NADPH as a co-factor (Islam et al., 2010
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