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Biochem J 1975

Second, biomarkers of disease severity could be useful in clinical trials as early markers of treatment response

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Crucially, this crisis extends beyond energy failure: phospholipase-driven lipid membrane degradation unleashes free fatty acids that oxidize mitochondria, permeabilize lysosomes, and ignite pyrin domain-containing protein 3 (NLRP3) inflammasomes [17,18,19]
