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These are separate B12-dependent pathways, and the cofactor requirements are not interchangeable. When your adenosylcobalamin status is low whether from inadequate intake, poor conversion, or impaired mitochondrial B12 transport MUT activity drops, methylmalonyl-CoA accumulates, and MMA rises

pomegranate log AUC differences, using a linear model with age group, sex, and their interaction as predictors, revealed a significant age sex interaction on the intervention effect ( P = 0.004), indicating that the identified difference by age varied with participant sex

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