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This is associated with an inflammatory phenotype and can promote neurodegeneration

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However, the expressions of AANAT and ASMT exhibit a circadian rhythm that matched the fluctuation in melatonin levels only in the mitochondria of pineal gland while this rhythm was absent in the mitochondria of neuronal cells [55]

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The bone remodeling cycle

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Source: O'Leary, F., & Samman, S

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