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HN acts extrinsically by binding to a dimeric or trimeric cytokine receptor complex followed by activation of STAT3 and ERK1/2 [17, 21,22,23]
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This suggests that B vitamin supplementation may provide therapeutic benefits in reducing cognitive decline related to high HCY levels [326]
We recently showed that GSH deficiency epigenetically alters VD-biosynthesis pathway genes in HFD-fed obese mice
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