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Therefore, the subsequent PI3K/Akt impairment suppresses this vital Nrf2-mediated antioxidant defenses while concurrently activating NFB-driven inflammation, thereby exacerbating mitochondrial ROS production and cytokine release (e.g., IL-6, TNF- , IL-1) in diabetic complications (41, 44)

doi: 10.1091/mbc.10.5.1637

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Traditional combination of chemotherapy with photodynamic therapy often suffers from high systemic toxicity, poor spatiotemporal coordination, and increased cumulative side effects