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These biochemical relationships demonstrate that folate availability and MTHFR activity define the upper limit for DNA and histone methylation, providing a mechanistic bridge to the epigenetic phenotypes described in autoimmune diseases (95-97,99)
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doi: 10.1038/nri3131 66 MommersteegM
The high rate of tumor cell survival, growth, and resistance to chemotherapy may be caused by thiamine supplementation (88) ( Table 2 )
