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When D1 receptors on MSNs are activated, the protein kinase A (PKA) signaling pathway is activated, leading to the inhibition of the inhibitory neurons in the GPi
This traps folate in its 5-methyltetrahydrofolate form and inhibits purine and thymidine synthesis for DNA, even when folate levels are sufficient (27)
C.BrewinJ
These are animal model findings and in vitro studies
