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Absorption: Conditions like celiac disease, IBS, or pernicious anemia can affect how your body takes in B12
The large amount doesn't pose a danger because people with pernicious anemia absorb only a small fraction of it

In a 2018 review, researchers found evidence that taking 1,000 mcg of B12 and getting B12 injections had similar effects on treating B12 deficiencies

This is an important distinction that ensures it is used within the proper scientific context
