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BD patients who started pharmacotherapy for the first time showed decreased cytokine production after 3 months of lithium treatment [77]

Thus, the combination of GATA-binding and E-box motifs contributes to specific transcriptional regulation by varying the DNA-binding characteristics and structure of the complex containing GATA1 and SCL, and possibly by varying other components of the complex (Figure 1)

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The kidney toxicity, the discontinued clinical trial, and the rise of highly effective GLP-1 agonists have all reduced its commercial viability

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