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Collectively, these findings underscore MMP suppression as a cornerstone of anti-metastatic therapy, with natural compounds offering multifaceted mechanisms to block ECM degradation, impair cell motility, and synergize with apoptotic and proliferation pathways

Although there are some links between TMAO and MAFLD and administration of TMAO impairs liver function and increases hepatic triglyceride accumulation and lipogenesis in animal models, whether reducing TMAO concentrations could prevent MAFLD remains unclear due to lack of relevant studies

References: Clark JM , Diehl AM

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The majority of the trials employed daily dosages of 1.52.0 g of LC, which were well tolerated (Wollen, 2010)