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These molecules typically target bacterial cell membranes, causing membrane disruption and bacterial death

In pathological conditions, an imbalance or abnormality of mitochondrial dynamics leads to morphological changes and dysfunction of mitochondria, which in turn triggers mitophagy

Pyrrolo(2,3-d)-pyrimidine derivatives such as NVP-AEW541, invented by Novartis, which show far greater (100 fold) selectivity towards IGF-1R over IR

Targeting off-target effects: endoplasmic reticulum stress and autophagy as effective strategies to enhance temozolomide treatment

Edaravone showed potent antioxidant and radical scavenging activities in various pathologies, such as cerebral ischemia, stroke and amyotrophic lateral sclerosis [202,203,204], also improving oxidative stress-induced mitochondrial impairment in various diseases [205,206]