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Nature 456 , 745749

The therapeutic range in epilepsy is commonly considered to be 50 to 100 mcg/mL of total valproate, although some patients may be controlled with lower or higher plasma concentrations

In patients manifesting with neurologic abnormalities there are often associated dysmorphic features, including prominent metopic suture (persistence of the space between the frontal bones of the skull), a downturned mouth, bilateral ptosis (drooping eyelid), and limb contractures

The heart, brain, muscles, and testicles contain considerable concentrations of ALC but the levels are dramatically reduced as we age

doi:10.1016/s1808-8694(15)31266-0