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DNA is usually methylated on the fifth position of the cytosine base in mammals, generating 5-methyl-cytosine (5mC), which is catalyzed by DNMTs, and the methyl group is removed by demethylases

Finally, microbiota-targeted interventions stemming from these mechanistic insights should be validated through large-scale, randomized controlled trials in high-altitude populations to ensure successful clinical translation

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(39, 42) elucidated that RSV treatment (20 and 40 mg/kg 7 days, i.p.) corrected dysfunction of inflammation-related transcription factor signaling