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Description
In some cases, the sequential use of different B12 status biomarkers or the calculation of a composite B12 status score (derived from a panel of B12 biomarkers and adjusted for folate status and age) can be used to detect deficient states that may otherwise be overlooked when using a single biomarker approach such as a B12 level (92)

Although not readily used in the UK due to ongoing regulatory ambiguities, they are increasingly prescribed in other countries and subject to intensive ongoing research

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Kennedy, B Vitamins and the Brain: Mechanisms, Dose and EfficacyA Review, Nutrients, vol

Lancet 2007;369:6070
