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However, in a similar study performed to evaluate the effects of pyruvate with increased frequency of dosing (500 mg/kg i.p., 6 days a week) in SOD1 G93A mice, pyruvate was not able to alter the onset of the disease or survival of mice (Esposito et al., 2007)

However, these improvements are subtle if patients are in the same relative area of the therapeutic range

Oxidative stress and ischemic myocardial syndromes
