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In addition, the activity and expression of SLC7A11 is strictly regulated by multiple mechanisms, such as transcription factor 4 (ATF4), nuclear factor erythroid 2related factor 2 (NRF2), ubiquitin BRCA1 (Breast cancer gene 1)-associated protein-1 (BAP1), the SWI/SNF complex, and rapamycin complex 1 (mTORC1) (51), through which the expression of SLC7A11 can be upregulated to enhance the antioxidant defense of cells and inhibit the occurrence of ferroptosis ( Figure 1B )

In contrast, anaplastic astrocytomas and IDH wild-type GBMs also harbor these mutations but have varying prognostic outcomes

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Results Defective in vivo response to eTLRs in Munc13-4 deficiency We previously showed that Munc13-4 binding to STX7 regulates the eTLR response to CpG 16