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[88] [89] The Australian Therapeutic Goods Administration has recommended no more than 250 mg of kavalactones be taken in a 24hour period
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PMID: 14 BostromB
Curr Med Chem 16:32673285
These studies demonstrate that chronic ethanol consumption results in dramatically increased levels of CYP2E1 (up to 20-fold) leading to increased production of reactive oxygen species (ROS), lower cellular antioxidant levels, and enhanced oxidative stress
