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Figure 8 4 Discussion Pro-inflammatory cytokines, TNF- and IL-6, have been linked to numerous CNS disorders including neurodegenerative diseases, autism spectrum disorder, psychiatric disorders, and more recently cognitive impairment associated with long-COVID (Lucas et al., 2006

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K.LiH.GummuluruS.et al (2014)

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from 5 to 95% phase B at 115.00 min

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TLRs signaling modulations Toll-like receptors (TLRs) are pivotal pattern recognition receptors that detect microbial components and host-derived danger-associated molecular patterns (DAMPs) at the wound site, initiating innate immune responses essential for infection control and tissue repair

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VidalAlaball J, Butler C, CanningsJohn R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A

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