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Commonly used markers such as p16^INK4a, SA--galactosidase, and SASP cytokines (eg, IL-6, IL-8) show promise in experimental models but have variable sensitivity and specificity across tissues and disease contexts.1 Their expression can be transient, context-dependent, and influenced by non-senescent cellular states, complicating interpretation in human studies

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Related to GHK-Cu (the copper-bound form) studied in the Pickart & Margolina review

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