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3.1.4 MAPKs (ERK, p38, JNK) The mitogen-activated protein kinase (MAPK) family comprises key signaling molecules, including ERK, MAPK, and JNK, that regulate cellular responses such as proliferation, apoptosis, inflammation, and fibrosis

In line with these reports, our data demonstrate that exogenous fetuin-A and LECT2 directly suppressed insulin-stimulated Akt phosphorylation in both adipocytes and myotubes, indicating their causal roles in peripheral IR

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The seamless functioning of this mechanism is crucial for maintaining cellular homeostasis