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found that rapamycin (20 nM) combined with arsenic trioxide (0.5 and 1 M) has a synergistic antiproliferative and pro-apoptosis effect on AML cell lines (HL-60 and U-937) and primary AML cells that lack typical t (15;17) translocation

Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes

C., Eagleson K

Markland FS, Swenson S

Many patients exhibit: Heat sensitivity Stress-triggered flushing Rapid redness changes Burning sensations This suggests dysregulation involving: Mast cells Nervous system signaling Blood vessel reactivity Stress, poor sleep, and cortisol dysregulation may amplify these pathways