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In females, NAC accelerated the accumulation of delta and beta energy across QW during SD, whereas NAC suppressed the accumulation of delta and beta energy across QW during SD in males (days 16 and 18 as displayed in Figure 2

For instance, persistent DSB signaling can rewire cellular metabolism toward a suppressive state and enforce epigenetic changes that stabilize the exhausted transcriptional program (88)

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Importantly, most gastrointestinal events were mild-to-moderate in severity, and 92.8% of participants completed the full two-year trial, indicating that long-term tolerability was generally good