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4245 Certain medications, eg, isoniazid, 5-fluorouracil, azathioprine, and 6-mercaptopurine, interfere with niacin synthesis and may induce pellagra in susceptible patients

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What does Vitamin B12 do and why do we need it

doi: 10.1021/bi9906773

For these individuals, vitamin B12 injections are often the most effective way to restore healthy B12 levels because they bypass the digestive system entirely, delivering the vitamin directly into the bloodstream for maximum absorption (around 95% compared to 25-50% for oral supplements)