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GHK-Cu (glycyl-L-histidyl-L-lysine-copper) is a naturally occurring tripeptide - three amino acids bound to a copper ion

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These residues can undergo oxidation to form disulphide bonds and thus reduce PDI or an equivalent ER oxidoreductase

This technology involves genetic modification of parent cells, membrane modification, or in vitro modification of isolated vesicles to enhance their therapeutic efficacy or compensate for the limitations of natural EVs

DOI:10.3390/biomedicines9070792 Seiwerth.S, Milavic.M, Vukojevic.J, Stable Gastric Pentadecapeptide BPC 157 and Wound Healing