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Objective measures of strength are clear target outcomes in a disease of progressive weakness
However, it should be noted that WISP1, a trophic agent, also can promote tumorigenesis (281, 529, 636642)

Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi A, Shoji Y, Takada G, Matsuishi T, Yoshino M, Kato H, Ohura T, Tsujimoto G, Hayakawa J, Shimane M, Tsuji A: Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

Comparison of risk factors for initial central scotoma versus initial peripheral scotoma in normal-tension glaucoma
