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Despite their great potential, their clinical translation is often hindered by poor bioavailability and stability, rapid clearance and short half-life, low membrane permeability, which hinders their ability to cross cellular barriers and reach their intended targets, immunogenicity, and challenges regarding patentability and intellectual property protection

Not normally distributed data were analysed with the MannWhitney test and Dunns multiple comparison test

[DOI] [Google Scholar] 18.Martnez M.C., Andriantsitohaina R

Mol Neurobiol 53:30463062

[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Griess B., Tom E., Domann F., Teoh-Fitzgerald M