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This led to an increase in short-chain fatty acid levels, activation of AMPK, and regulation of lipid metabolism genes such as ACOX1, ACC, and FASN, ultimately reducing blood lipid levels (223)

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This metabolite not only traverses the BBB to inhibit A aggregation via direct interaction but also facilitates A clearance mediated by microglia through the ApoE-TREM2 signaling pathway [205]

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Supplied in a 3 mL vial as a lyophilized (freeze-dried) powder requiring reconstitution with a laboratory diluent