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Sometimes SAG is used in autoimmune diseases that have a neurological component involved

7.3 Sustainability and cost-effectiveness The pursuit of sustainable and cost-effective strategies is paramount for the clinical translation of curcumin-loaded nanoparticle delivery systems

In PDAC, shGOT1 cells displayed a consistent accumulation of glycolytic intermediates between the aldolase-catalyzed and pyruvate kinase-catalyzed steps of glycolysis, suggesting that GOT1 inhibition uniquely disrupted glycolysis pathways ( (G6PC3) both during normal growth conditions and after glucose deprivation and the down-regulated expression of the glucose-controlling gene BIP after glucose deprivation, indicating GOT1s roles in glucose metabolism (59)

E., Loscalzo J

Additionally, the interaction between alpha-synuclein and phospholipids in cell membranes can generate ROS, further exacerbating oxidative damage and neuronal dysfunction [163]