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If the TrxR1-, Gsr-, and Met-driven disulfide reductase systems play distinct roles in signaling and redox homeostasis, then it might be possible to target these pathways to selectively impact specific signaling activities versus homeostatic activities

EGCGs therapeutic window varies based on target condition and patient factors, with high doses potentially leading to adverse effects like hepatotoxicity

Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion

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[PMC free article: PMC294537] [PubMed: 8201014] 486