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Advanced glycation end products increase permeability of brain microvascular endothelial cells through reactive oxygen species-induced vascular endothelial growth factor expression

That is why higher concentrations exist

doi: 10.1016/j.cell.2024.12.005 79 LiuWXiaLPengYCaoQXuKLuoHet al

CozziBGiacomelloMZambenedettiPBologninSRossipalEPeruffoAet alOntogenesis and migration of metallothionein I/II-containing glial cells in the human telencephalon during the second trimester

If patients experience side effects like prolonged blurry vision or significant eye pain after Eylea treatment, they should contact their eye doctor