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[35] Optically active (R)- and (S)-4-chloro-3-hydroxybutyrates were loaded on a capillary column G-TA (30 m x 0.32 mm, Astec) which was then heated at 120 0 C for 10 min, elevated to 170 0 C at a rate of 10 C/min, and maintained at 170 0 C for 15 min

Since changes in pigmentation can be readily visualized, early work on melanocortin ligands focused on the MC1R

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